Fitness costs of antibiotic resistance mutations in rich media do not reliably predict those in infection-like environments
Jack Knowles, Lauren Pittaccio, Selina Lindon, Corey Woods, Danna R. Gifford, Lisa Juliane Kahl, R. Craig MacLean, Simon J. S. Cameron, Rachel M. Wheatley
The study shows that fitness costs of antibiotic resistance mutations in rich media do not reliably predict their costs in infection-like environments, with increased costs in lung-mimicking media and reduced prevalence in urinary tract-mimicking media.
bioRxiv · Sep 8, 2026 · PreprintMicrobiology