Osteocyte death and bone overgrowth in mice lacking Fibroblast Growth Factor Receptors 1 and 2 in mature osteoblasts and osteocytes
Jennifer A. McKenzie, Craig R. Smith, Kannan Karuppaiah, Joshua Langberg, Matthew J. Silva, David M. Ornitz
This study shows that loss of FGFR1 and FGFR2 in mature osteoblasts/osteocytes leads to osteocyte death and high bone mass with impaired biomechanical properties in mice.
Journal of Bone and Mineral Research · Jun 17, 2019Peer-reviewedDevelopmental Biology