Matthew J. Silva

Fibroblast Growth Factor Receptor Signaling in Maturing Osteoblasts Controls Cell-Matrix Interactions Critical for Osteocyte Survival

This study shows FGFR1 signaling is essential for osteocyte survival and bone homeostasis by regulating extracellular matrix organization and dendrite formation in maturing osteoblasts.

Protocol for 3D digital dynamic histomorphometry of bone via time-lapse registration of serial microCT scans

This paper describes a protocol using microCT scans and Dragonfly for quantifying bone remodeling in rodents over time without coding expertise.

Spatial transcriptomics for gene discovery identifies Slc13a5 as a modulator of bone mechanoadaptation

This study uses spatial transcriptomics to identify Slc13a5 as a regulator of bone mechanoadaptation, showing its role in mineralization and resorption under mechanical loading.

Combination Treatment with Sclerostin and Dkk1 Antibodies Synergizes with Tibial Loading to Stimulate Bone Formation in Aged Mice

This study shows that combining Sclerostin and Dkk1 antibodies with mechanical loading significantly enhances bone formation in aged mice.

VEGFA critically controls neurovascular invasion and chronic low back pain during intervertebral disc degeneration

This study shows that VEGFA drives neurovascular invasion in degenerating intervertebral discs and contributes to chronic low back pain, with its inhibition preventing pain behaviors.

Proliferation of Early and Mature Osteoblasts Is Required for Bone Fracture Healing in Mice

This study shows that proliferation of early and mature osteoblasts is essential for bone fracture healing in mice, as blocking their proliferation leads to fibrous nonunion and reduced callus formation.

Spatial histomorphometry reveals that local peripheral nerves modulate but are not required for skeletal adaptation to applied load in mice

Multi-Scale Cortical Bone Traits Vary in Two Mouse Models of Genetic Diversity

This study examines how genetic diversity affects multi-scale cortical bone traits in two mouse populations, finding significant heritability and hybrid phenotypes in outbred mice.

Osteoblast-Specific Wnt Secretion is Required for Skeletal Homeostasis and Loading-Induced Bone Formation in Adult Mice

This study shows that osteoblast-specific Wnt secretion is essential for maintaining bone homeostasis and the anabolic response to mechanical loading in adult mice.

Osteocyte death and bone overgrowth in mice lacking Fibroblast Growth Factor Receptors 1 and 2 in mature osteoblasts and osteocytes

This study shows that loss of FGFR1 and FGFR2 in mature osteoblasts/osteocytes leads to osteocyte death and high bone mass with impaired biomechanical properties in mice.