TyCHE enables time-resolved lineage tracing of heterogeneously-evolving populations
Jessie J. Fielding, Sherry Wu, Hunter J. Melton, Crystal Z. Wang, Nic Fisk, Louis du Plessis, Kenneth B. Hoehn
TyCHE improves time-resolved lineage tracing by accounting for heterogeneous mutation rates, applied to memory B cells, germinal centers, gliomas, and bacterial infections.
bioRxiv · Oct 21, 2025 · PreprintImmunology