Hunter J. Melton

This study examines how maternal vaccination timing affects antibody clonotype transfer to newborns, finding that earlier vaccination leads to more diverse but less persistent clonotypes, while later vaccination results in more persistent, affinity-matured antibodies in cord blood.

This paper develops a zero-inflated hierarchical generalized transformation model to improve cell-type deconvolution in spatial transcriptomics data from oral squamous cell carcinomas.

TyCHE improves time-resolved lineage tracing by accounting for heterogeneous mutation rates, applied to memory B cells, germinal centers, gliomas, and bacterial infections.

SUMMIT-FA improves gene expression prediction accuracy using functional annotations and eQTL data, enhancing gene-trait association detection in GWAS.

MIMOSA improves DNA methylation prediction and MWAS power by integrating summary-level mQTL data, identifying more CpG-phenotype associations in whole blood.