Kenneth B. Hoehn

This study analyzes 450 Pseudomonas aeruginosa isolates from CF patients to show structured population dynamics, migration, and parallel adaptive evolution within lung infections.

This study examines how maternal vaccination timing affects antibody clonotype transfer to newborns, finding that earlier vaccination leads to more diverse but less persistent clonotypes, while later vaccination results in more persistent, affinity-matured antibodies in cord blood.

The paper identifies long-lived IgE plasma cells in the spleen that persist after immunization and contribute to sustained IgE responses in mice.

TyCHE improves time-resolved lineage tracing by accounting for heterogeneous mutation rates, applied to memory B cells, germinal centers, gliomas, and bacterial infections.

This study shows that pre-Omicron immunity generates IgG+ but not IgA+ memory B cells reactive to Omicron spike protein, indicating broad antigenic recognition but weakened mucosal antibody defense.