One-carbon metabolism controls colorectal cancer cell state and chemosensitivity through chromatin remodeling
Laura Vízkeleti, Csaba Kiss, Viktória Tisza, Anna Zichy, Arnold Markovics, Alexandra Kalmár, Pál Tamás Szabó, István Csabai, Lőrinc Sándor Pongor, Sándor Spisák, Bela Akos Molnar
This study shows that folate metabolism remodels epithelial states in colorectal cancer cells, affecting their response to fluoropyrimidine chemotherapy.
bioRxiv · Oct 2, 2026 · PreprintMolecular Biology