Mitochondrial dysfunction heightens the integrated stress response to drive ALS pathogenesis
Curran Landry, James Costanzo, Miguel Mitne‐Neto, Mayana Zatz, Ashleigh E. Schaffer, Maria Hatzoglou, Alysson Renato Muotri, Helen C. Miranda
This study shows that VAPB P56S mutation causes mitochondrial dysfunction and enhances the integrated stress response, leading to motor neuron disease in ALS.
bioRxiv · May 13, 2024 · PreprintNeuroscience