Author

James Costanzo

Case Western Reserve UniversityPrimary ORCID profile (0009-0004-6642-6634 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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James CostanzoiD1 paper · Vanderbilt University

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Neuroscience· 1

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Alysson Renato MuotriiD· 1 shared Ashleigh E. SchafferiD· 1 shared Curran Landry· 1 shared Helen C. MirandaiD· 1 shared Maria HatzoglouiD· 1 shared Mayana ZatziD· 1 shared Miguel Mitne‐NetoiD· 1 shared

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2024-2024 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Alysson Renato MuotriORCID

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1 paper

Recent·Most cited

Mitochondrial dysfunction heightens the integrated stress response to drive ALS pathogenesis

Curran Landry, James Costanzo, Miguel Mitne‐Neto, Mayana Zatz, Ashleigh E. Schaffer, Maria Hatzoglou, Alysson Renato Muotri, Helen C. Miranda

This study shows that VAPB P56S mutation causes mitochondrial dysfunction and enhances the integrated stress response, leading to motor neuron disease in ALS.

bioRxiv · May 13, 2024 · PreprintNeuroscience