Werner syndrome helicase modulates G4 DNA-dependent transcription and opposes mechanistically distinct senescence-associated gene expression programs
Weiliang Tang, Ana I. Robles, Richard P. Beyer, Lucas T. Gray, Giang Hong Nguyen, Junko Oshima, Nancy Maizels, Curtis C. Harris, Raymond J. Monnat
This study examines mRNA and miRNA expression changes in Werner syndrome patient fibroblasts and WRN-depleted cells, revealing WRN's role in modulating G4 DNA-dependent transcription and distinct senescence-associated gene programs.
bioRxiv · Aug 4, 2015Genetics