Nancy Maizels

The paper identifies mutagenic signatures at DNA nicks by analyzing repair factors and their effects on different types of mutations.

The paper shows that G-quadruplexes bind heme in vitro and that displacing heme from quadruplexes increases heme degradation gene expression in human cells.

This paper demonstrates that targeted interhomolog recombination (IHR) can correct genetic mutations with increased efficiency using CRISPR/Cas9-induced DSBs and POLQ depletion.

This study examines mRNA and miRNA expression changes in Werner syndrome patient fibroblasts and WRN-depleted cells, revealing WRN's role in modulating G4 DNA-dependent transcription and distinct senescence-associated gene programs.