Curtis C. Harris

This study shows that Δ133p53α extends lifespan and improves tissue health in a progeria mouse model, suggesting potential therapeutic applications for both progeria and ageing.

This study shows that Δ133p53 reduces CXCL10 levels in progeria and aged mice, linking it to anti-inflammatory effects.

This study shows that knocking down SRSF3 induces cellular senescence in NSCLC cells, including those without targetable mutations, suggesting a potential new therapeutic strategy.

This study shows that celastrol and AZD1981 increase Δ133p53 levels and reduce senescence and IL-6 secretion in HGPS-derived fibroblasts, independent of progerin levels.

ProCanFDL uses federated deep learning to subtype cancers using proteomic data while preserving privacy, achieving performance gains over local models.

This study identifies Matrin3's role in regulating CDC14B alternative splicing, which affects cell proliferation and mitotic spindle dynamics in colorectal cancer cells.

This paper shows that Δ133p53α protects human astrocytes from amyloid-beta-induced senescence and neurotoxicity by preventing DNA damage and SASP.

The paper introduces a functional genomic complexity (FGC) score to assess genomic heterogeneity in liver cancer, finding higher FGC correlates with worse prognosis and immune evasion.

This study identifies three novel genomic regions associated with lung cancer risk in African Americans, showing pleiotropic effects across multiple cancers.

This study identifies a microbiome-TP53 interaction in squamous cell lung cancer, showing Acidovorax enrichment in smokers with TP53 mutations.

This study examines mRNA and miRNA expression changes in Werner syndrome patient fibroblasts and WRN-depleted cells, revealing WRN's role in modulating G4 DNA-dependent transcription and distinct senescence-associated gene programs.