The role of aging on endothelial cell-cell junctions and pulmonary microvascular permeability
Aminmohamed Manji, Lefeng Wang, Cynthia Pape, Sanjay Mehta, Preya Patel, Samuel-Caleb Yeung, Eric K. Patterson, Antoine Dufour, Daniel W Young, Ruud A. W. Veldhuizen, Sean E. Gill
This study shows that aging increases pulmonary microvascular endothelial cell permeability due to impaired cell-cell junctions and actin cytoskeleton changes, not inflammation.
bioRxiv · Jul 29, 2025 · PreprintCell Biology