Antoine Dufour

The paper shows that biomanufacturing conditions alter molecular states in hiPSCs without losing pluripotency, linking these changes to developmental programs.

This study shows that EMMPRIN promotes pro-inflammatory metabolism in monocytes/macrophages, worsening multiple sclerosis, and its deletion reduces disease severity.

This study shows that elamipretide improves cardiac function and prevents mortality in sepsis-induced cardiac dysfunction in mice by restoring mitochondrial function.

This study shows that restoring calpastatin activity improves motor neuron function and survival in C9orf72 ALS models by enhancing synaptic proteolysis and NMJ integrity.

The paper identifies a sub-population of synovial mesenchymal stem cells (MSCs) with enhanced treatment efficacy in a rat OA model using proteomics and transplantation.

This study identifies extracellular matrix genes that reduce rapamycin response in LAM cells and suggests repurposed inhibitors as potential therapies.

This study shows that aging increases pulmonary microvascular endothelial cell permeability due to impaired cell-cell junctions and actin cytoskeleton changes, not inflammation.

This study uses fecal proteomics to show how season, diet, age, and sex affect gut physiology in wild capuchins.

This study surveys Canadian early-career health researchers to assess pandemic impacts, revealing high burnout rates and mental health declines.

This study identifies redox signaling and IL-6 as key regulators of adipogenesis in adipose progenitor cells under obesogenic conditions.

This study identifies Cystatin C as a glucocorticoid-responsive factor that recruits Trem2+ macrophages and predicts immunotherapy failure in cancer.

The paper identifies proteolytic events in neurons during excitotoxicity using N-terminomics, revealing calpain-mediated cleavage of synaptic proteins and potential therapeutic targets for neuroprotection.