MacroH2A1 and H3K27me3 target cGAS to facultative heterochromatin to restrain innate immune activation
Suzie Thenin-Houssier, Cyprien Jahan, Wenjie Xu, Giorgio Lucio Papadopoulos, Lucie Bonnet‐Madin, Syota Matsumoto, Tomoya Kujirai, Olivier Cuvier, Hitoshi Kurumizaka, Bijan Sobhian, Monsef Benkirane
This study shows that macroH2A1 and H3K27me3 bind cGAS to sequester it in heterochromatin, preventing innate immune activation.
bioRxiv · Oct 9, 2026 · PreprintCell Biology