In vitro discovery of a therapeutic lead for HFMD from a library screen of rocaglates/aglains
Adrian Oo, Angel Borge, Regina Ching Hua Lee, Cyrill Kafi Salim, Wenyu Wang, Michael Ricca, Yuhui Deborah Fong, Sylvie Alonso, Lauren E. Brown, John A. Jr. Porco, Justin Jang Hann Chu
This study identifies a novel aglain derivative that effectively inhibits EV-A71 replication and shows broad antiviral activity against enteroviruses.
Journal of Medical Virology · Feb 1, 2025Peer-reviewedMicrobiology