A ML-framework for the discovery of next-generation IBD targets using a harmonized single-cell atlas of patient tissue
Anoushka Joglekar, Ann Joseph, Pavel Honsa, Klara Ruppova, Veronica Pizzarella, Amanda M. Honan, Devin Mediratta, Emily Vollmer, Evan T. Geller, Martin Valný, Eva Macuchova, Shiwei Zheng, Alisa Greenberg, Petr Tauš, Alina R. Kline-Schoder, , Adeeb H Rahman
The paper develops a machine learning framework to identify cell type-specific gene targets for IBD using a harmonized single-cell atlas and validates them experimentally.
bioRxiv · May 10, 2026 · PreprintBioinformatics