Author

D. A. Ghose

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Evolutionary Biology· 1

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Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

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A. E. Keating· 1 shared E. M. Mahoney· 1 shared K. E. Przydzial· 1 shared M. T. Laub· 1 shared

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2023-2023 · peak 1/yr

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1 shared paperEvolutionary Biology

A. E. Keating

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1 paper

Recent·Most cited

Marginal specificity in protein interactions constrains evolution

D. A. Ghose, K. E. Przydzial, E. M. Mahoney, A. E. Keating, M. T. Laub

This study shows that bacterial signaling paralogs have marginal specificity, where many single mutations can cause cross-talk, constraining their evolution.

bioRxiv · Feb 18, 2023 · PreprintEvolutionary Biology