Cancer BiologybioRxiv
The Repertoire of Mutational Signatures in Human Cancer
L. Alexandrov, J. Kim, N. J. Haradhvala…·M. R. Stratton
The paper characterizes 49 mutational signatures in human cancer using a large dataset of somatic mutations, revealing associations with exposures and DNA repair mechanisms and identifying signatures of unknown origin.
DOI 10.1038/s41586-020-1943-3