Author

M. R. Stratton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 7 Organism:human· 6 Approach:statistical model· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

H. Lee-Six· 2 shared I. Martincorena· 2 shared J. Wang· 2 shared K. Saeb-Parsy· 2 shared L. Alexandrov· 2 shared L. Moore· 2 shared M. A. Sanders· 2 shared P. Ellis· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

H. Lee-Six

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The evolution of two transmissible cancers in Tasmanian devils

M. R. Stammnitz, K. Gori, Y. M. Kwon, E. Harry, F. J. Martin, K. Billis, Y. Cheng, A. Baez-Ortega, W. Chow, S. Comte, H. Eggertsson, S. Fox, R. Hamede, M. E. Jones, B. Lazenby, , E. P. Murchison

This study analyzes the genetic diversity and evolution of two transmissible cancers in Tasmanian devils, revealing their emergence dates, mutation rates, and evolutionary patterns.

bioRxiv · May 27, 2022Cancer Biology

An international report on bacterial communities in esophageal squamous cell carcinoma

J. Nomburg, S. Bullman, D. Nasrollahzadeh, E. A. Collisson, B. Abedi-Ardekani, L. O. Akoko, J. R. Atkins, G. C. Buckle, S. Gopal, N. Hu, B. Kaimila, M. Khoshnia, R. Malekzadeh, D. Menya, B. T. Mmbaga, , K. Van Loon

This study identifies bacterial communities associated with esophageal squamous cell carcinoma (ESCC) tumors and finds similar enrichment of oral bacteria in both saliva and tumor microbiomes of ESCC patients.

bioRxiv · Sep 29, 2021Microbiology

The APOBEC3A deaminase drives episodic mutagenesis in cancer cells

M. Petljak, K. Chu, A. Dananberg, E. N. Bergstrom, P. von Morgen, L. Alexandrov, M. R. Stratton, J. Maciejowski

This study shows that APOBEC3A drives episodic mutagenesis in cancer cells by reducing clustered mutations and identifying key enzymes involved in mutation generation.

bioRxiv · Feb 14, 2021 · PreprintCancer Biology

The Repertoire of Mutational Signatures in Human Cancer

L. Alexandrov, J. Kim, N. J. Haradhvala, M. N. Huang, A. W. T. Ng, Y. Wu, A. Boot, K. R. Covington, D. A. Gordenin, E. Bergstrom, S. M. A. Islam, N. Lopez-Bigas, L. J. Klimczak, J. R. McPherson, S. Morganella, , M. R. Stratton

The paper characterizes 49 mutational signatures in human cancer using a large dataset of somatic mutations, revealing associations with exposures and DNA repair mechanisms and identifying signatures of unknown origin.

bioRxiv · Jul 3, 2019Cancer Biology

Comprehensive Analysis of Indels in Whole-genome Microsatellite Regions and Microsatellite Instability across 21 Cancer Types

A. Fujimoto, M. Fujita, T. Hasegawa, K. Maejima, K. Nakano, A. Oku-Sasaki, J. H. Wong, Y. Shiraishi, S. Miyano, S. Imoto, M. R. Stratton, S. G. Rosen, H. Nakagawa

The paper analyzes microsatellite mutations across 21 cancer types, identifies MSI cancers, and finds factors influencing mutation rates and functional impacts.

bioRxiv · Feb 22, 2019Cancer Biology

The mutational landscape of normal human endometrial epithelium

L. Moore, D. Leongamornlert, T. H. Coorens, M. A. Sanders, P. Ellis, K. Dawson, F. Maura, J. Nangalia, P. S. Tarpey, S. F. Brunner, H. Lee-Six, R. Rahbari, S. Moody, Y. Hooks, K. Mahbubani, , M. R. Stratton

This study characterizes the mutational landscape of normal human endometrial epithelium, revealing age-related mutation burdens and driver mutations in cancer genes.

bioRxiv · Dec 24, 2018Cancer Biology

The landscape of somatic mutation in normal colorectal epithelial cells

H. Lee-Six, P. Ellis, R. J. Osborne, M. A. Sanders, L. Moore, N. Georgakopoulos, F. Torrente, A. Noorani, M. Goddard, P. Robinson, T. H. H. Coorens, L. O'Neill, C. Alder, J. Wang, R. C. Fitzgerald, , M. R. Stratton

This study whole genome sequences normal colorectal crypts to reveal mutational processes and driver mutations in morphologically normal tissue, showing neoplastic changes are pervasive.

bioRxiv · Sep 13, 2018Cancer Biology