Author

D. A. Novack

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Cancer Biology· 1

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Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

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G. Acker· 1 shared L. Qian· 1 shared R. H. G. Baxter· 1 shared V. A. Voelz· 1 shared

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2022-2022 · peak 1/yr

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1 shared paperCancer Biology

G. Acker

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1 paper

Recent·Most cited

Oncogenic mutations in the DNA-binding domain of FOXO1 disrupt folding: quantitative insights from experiments and molecular simulations

D. A. Novack, L. Qian, G. Acker, V. A. Voelz, R. H. G. Baxter

This study investigates how specific mutations in the DNA-binding domain of FOXO1 affect its folding stability using experimental and computational methods, finding that mutations like L183P and L183R significantly destabilize the protein structure.

bioRxiv · Apr 1, 2022Cancer Biology