L. Qian

Evaluation of Deep Neural Network Models for Instance Segmentation of Lumbar Spine MRI

This paper evaluates 15 DNN models for instance segmentation of lumbar spine MRI using a new synthetic dataset and two metrics.

Parallel Molecular Data Storage by Printing Epigenetic Bits on DNA

This paper introduces a DNA-based data storage method using epigenetic modifications, achieving scalable and parallel data writing and retrieval.

SARS-CoV-2 spike protein induces the cytokine release syndrome by stimulating T cells to produce more IL-2

This study identifies that SARS-CoV-2 spike protein induces cytokine release syndrome by enhancing T cell production of IL-2, which drives inflammatory cytokine release through TLR4 and NF-κB activation.

Fatty acid synthesis promotes inflammasome activation through NLRP3 palmitoylation.

This study shows that fatty acid synthesis promotes NLRP3 inflammasome activation through palmitoylation of NLRP3, with no effect on AIM2 inflammasome activation.

SIDERITE: Unveiling Hidden Siderophore Diversity in the Chemical Space Through Digital Exploration

SIDERITE identifies new iron-binding molecules by analyzing chemical structures and confirming their iron-binding ability through experimental validation.

HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

This study identifies HERC5-catalyzed ISGylation of cGAS as a mechanism that enhances antiviral innate immunity by modulating the cGAS-STING pathway.

Oncogenic mutations in the DNA-binding domain of FOXO1 disrupt folding: quantitative insights from experiments and molecular simulations

This study investigates how specific mutations in the DNA-binding domain of FOXO1 affect its folding stability using experimental and computational methods, finding that mutations like L183P and L183R significantly destabilize the protein structure.

The special and general mechanism of cyanobacterial harmful algal blooms

The paper examines the special and general mechanisms of cyanobacterial harmful algal blooms, identifying ecological and evolutionary factors that enable cyanobacteria to dominate under eutrophic conditions.

Conserved Transcription Factors Control Chromatin Accessibility and Gene Expression to Maintain Cell Fate Stability and Restrict Reprogramming of Differentiated Cells

This study identifies four conserved transcription factors that oppose cell fate reprogramming by controlling chromatin accessibility and gene expression, and shows their potential as therapeutic targets for regenerative medicine.

Cas9-cleavage sequences in minimal plasmids enhance non-viral genome targeting of CARs in primary human T cells

This paper develops a non-viral method for efficient T cell genome editing using modified plasmids, achieving CAR-T cell functionality comparable to AAV-based methods.

The study of lumbar ligamentum flavum hypertrophy induced in bipedal mice

This study induces bipedal posture in mice to create a model of lumbar ligamentum flavum hypertrophy and shows increased stress leads to degeneration.

E proteins orchestrate dynamic transcriptional cascades to suppress ILC2 differentiation

This study identifies E proteins as suppressors of ILC2 differentiation by repressing a transcriptional network through upregulation of repressor genes.