Author

D. A. Specht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

G. Lambert· 1 shared Y. Xu· 1 shared

Activity by Year

2019-2019 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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1 shared paperBiophysics

G. Lambert

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1 paper

Recent·Most cited

Massively parallel CRISPRi assays reveal concealed thermodynamic determinants of dCas12a binding

D. A. Specht, Y. Xu, G. Lambert

This study uses CRISPRi assays to analyze the thermodynamic factors influencing FnCas12a DNA binding, identifying key determinants for improving crRNA design and reducing off-target effects.

bioRxiv · Oct 24, 2019Biophysics