Pre-existing Subclones Determine Radioresistance in Rectal Cancer Organoids
D. Andel, B. Viergever, N. Peters, D. Raats, S. van Schelven, M. Intven, M. Zandvliet, J. Hagendoorn, I. Borel Rinkes, O. Kranenburg
This study shows that pre-existing subclones in rectal cancer organoids determine radioresistance, with resistance linked to reduced chromosomal instability.
bioRxiv · Nov 2, 2023Cancer Biology