Author

O. Kranenburg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

E. Kucukkose· 2 shared H. J. G. Snippert· 2 shared J. van Rheenen· 2 shared O. J. Sansom· 2 shared A. A. Khalil· 1 shared A. D. Campbell· 1 shared A. Fumagalli· 1 shared A. Gusinac· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

E. Kucukkose

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5 papers

Recent·Most cited

Pre-existing Subclones Determine Radioresistance in Rectal Cancer Organoids

D. Andel, B. Viergever, N. Peters, D. Raats, S. van Schelven, M. Intven, M. Zandvliet, J. Hagendoorn, I. Borel Rinkes, O. Kranenburg

This study shows that pre-existing subclones in rectal cancer organoids determine radioresistance, with resistance linked to reduced chromosomal instability.

bioRxiv · Nov 2, 2023Cancer Biology

Stromal localization of inactive CD8+ T cells in metastatic mismatch repair deficient colorectal cancer

E. Kucukkose, M. J. D. Baars, M. Amini, S. J. Schraa, E. Floor, G. M. Bol, I. H. M. B. Rinkes, J. M. L. Roodhart, M. Koopman, J. Laoukili, O. Kranenburg, Y. Vercoulen

The paper identifies stromal localization of inactive CD8+ T cells in metastatic MSI-H CRC and links it to poor immune response.

bioRxiv · Oct 9, 2023Cancer Biology

Mechanical regulation of cell fate transitions underlying colorectal cancer metastasis formation

M. C. van der Net, M. J. Vliem, L. J. S. Kemp, C. Perez-Gonzalez, E. A. Strating, A. Krotenberg-Garcia, R. M. Houtekamer, K. B. van den Anker, J. L. Monster, H. J. G. Snippert, A. A. Khalil, J. van Rheenen, S. J. Suijkerbuijk, O. Kranenburg, D. Matic Vignjevic, M. Gloerich

This study shows that mechanical signals from the Collagen I-rich matrix drive fate transitions in colorectal cancer cells, enabling metastasis despite lacking Lgr5 expression.

bioRxiv · Sep 17, 2023 · PreprintCancer Biology

Mutation-induced phenotypic plasticity drives formation of a pro-metastatic tumour-intrinsic niche

J. M. Bugter, L. El Bouazzaoui, E. Kucukkose, M. L. Mills, Y. Hong, J. Sprangers, I. Jordens, D. Kokkinidi, S. Plugge, A. Venhuizen, S. Bosman, J. Hageman, N. Fenderico, K. Gilroy, D. Montiel Gonzalez, , M. M. Maurice

This study identifies mutation-induced phenotypic plasticity as a driver of a pro-metastatic tumour-intrinsic niche in BRAF-mutant colorectal cancer.

bioRxiv · Dec 22, 2022 · PreprintCancer Biology

Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

A. Sacchetti, M. Teeuwssen, M. Verhagen, R. Joosten, T. Xu, R. Stabile, B. van der Steen, M. M. Watson, A. Gusinac, W. K. Kim, I. Ubink, H. J. van de Werken, A. Fumagalli, M. Paauwe, J. van Rheenen, , R. Fodde

This study identifies EpCAMlo colon cancer cells with phenotypic plasticity, linking Wnt/β-catenin signaling and EMT activation to metastasis and poor prognosis.

bioRxiv · Jul 24, 2020Cancer Biology