Healing of Primary and Recurrent Mouse Ocular Herpetic Disease Following Topical Ocular Treatment with an Engineered Fibroblast Growth Factor-1 (FGF-1) is Associated with Increased Frequency and Function of Corneal Anti-Inflammatory M2 Macrophages
N. Dhanushkodi, R. Srivastava, P.-G. Coulon, S. Prakash, S. Roy, D. Bagnol, D. Eveleth, L. BenMohamed
This study shows that engineered FGF-1 (TTHX1114) reduces HSV-1-induced corneal disease in mice by increasing anti-inflammatory M2 macrophages and decreasing pro-inflammatory M1 macrophages.
bioRxiv · Nov 25, 2020Immunology