R. Srivastava

Transpiration efficiency variations in the pearl millet reference collection PMiGAP

This study analyzes transpiration efficiency (TE) variation in 538 pearl millet genotypes across multiple environments, finding up to two-fold variation and highlighting its importance for drought tolerance and breeding.

Lack of Purple Acid Phosphatase SlPAP26b compromises the phosphorous starvation response in tomato independent of SlPHR1 and SlPHL1

This study identifies SlPAP26b as a key player in tomato's phosphorus starvation response, independent of SlPHR1 and SlPHL1, through transcriptomics and proteomics analysis.

Rewiring native post-transcriptional carbon regulators to build multi-layered genetic circuits and optimize engineered microbes for bioproduction

This paper rewires the Csr Network in E. coli to create tunable genetic circuits for post-transcriptional control, achieving three-fold increased mevalonate production.

Anti-Viral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein Against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models

This study shows RAGE-Ig reduces viral replication and inflammation in multiple SARS-CoV-2 variants using animal models and human cells.

Development of a human glioblastoma model using humanized DRAG mice for immunotherapy

This study develops a humanized DRAG mouse model to test GBM immunotherapy, showing anti-PD-1 antibodies reduce immunosuppressive cells in xenografted tumors.

High Frequencies of Phenotypically and Functionally Senescent and Exhausted CD56+CD57+PD-1+ Natural Killer Cells, SARS-CoV-2-Specific Memory CD4+ and CD8+ T cells Associated with Severe Disease in Unvaccinated COVID-19 Patients

This study identifies increased exhaustion and senescence markers in NK and T cells of unvaccinated symptomatic COVID-19 patients, correlating with severe disease.

A Prime/Pull RR2/CXCL11 Therapeutic Vaccine that Bolsters the Number and Function of Dorsal Root Ganglia Tissue-Resident HSV-Specific CD8+ TRM Cells Protects Latently Infected Guinea Pigs from Recurrent Genital Herpes

This study develops a prime/pull vaccine using RR2 and CXCL11 to increase tissue-resident CD8+ TRM cells, reducing HSV-2 reactivation and genital herpes severity in guinea pigs.

Monoallelically-expressed Noncoding RNAs form nucleolar territories on NOR-containing chromosomes and regulate rRNA expression

The paper identifies SNULs, noncoding RNAs that form nucleolar territories on NOR chromosomes and regulate rRNA expression by influencing pre-rRNA sorting and processing.

Antiviral CD19+CD27+ Memory B Cells Are Associated with Protection from Recurrent Asymptomatic Ocular Herpes Infection

The paper identifies increased frequencies of HSV-specific memory B cells in asymptomatic individuals and mice, correlated with memory Tfh cells, suggesting their role in protection against recurrent ocular herpes.

High Frequencies of PD-1+TIM3+TIGIT+CTLA4+ Functionally Exhausted SARS-CoV-2-Specific CD4+ and CD8+ T Cells Associated with Severe Disease in Critically ill COVID-19 Patients

Dysfunctional Senescent Herpes Simplex Virus Specific CD57+CD8+ T cells are Associated with Recurrent Symptomatic Herpes in Humans

The paper identifies dysfunctional senescent HSV-specific CD8+ T cells in symptomatic herpes patients compared to asymptomatic individuals, linking senescence to recurrent herpes susceptibility.

Age-Related Impairment of Innate and Adaptive Immune Responses Following Intranasal Herpes Simplex Infection

This study investigates age-related immune impairments in mice following HSV-1 infection, finding reduced type-I interferon production and impaired CD8+ T cell function in aged mice.

Healing of Primary and Recurrent Mouse Ocular Herpetic Disease Following Topical Ocular Treatment with an Engineered Fibroblast Growth Factor-1 (FGF-1) is Associated with Increased Frequency and Function of Corneal Anti-Inflammatory M2 Macrophages

This study shows that engineered FGF-1 (TTHX1114) reduces HSV-1-induced corneal disease in mice by increasing anti-inflammatory M2 macrophages and decreasing pro-inflammatory M1 macrophages.

COVID19: Exploring uncommon epitopes for a stable immune response through MHC1 binding

This study identifies four SARS-CoV-2 proteins with strong HLA-1 binding and low energy that could serve as subunit vaccine candidates through immuno-informatics analysis.

Sustained anti-obesity effects of life-style change and anti-inflammatory interventions after conditional inactivation of the activin receptor ALK7

This study shows that combining ALK7 inhibition with lifestyle or anti-inflammatory interventions leads to sustained weight loss in obese mice, even under high caloric intake.

Design and Development of Point of Care Test and Optical Reader for Early Screening of Kidney Related Disorder

The paper develops low-cost, paper-based colorimetric assays and a reflectance-based optical reader for early screening of kidney-related disorders using urine samples.

IRF8 Governs Tumor-Associated Macrophage Control of T Cell Exhaustion

This study identifies IRF8 as a key factor in tumor-associated macrophages (TAMs) that induce T cell exhaustion by presenting cancer antigens, and shows its association with poor patient survival in renal cell carcinoma.

The roles of microtubules and membrane tension in axonal beading, retraction, and atrophy

This study investigates how microtubules and membrane tension drive axonal beading, retraction, and atrophy in neurodegenerative conditions through controlled experiments and theoretical analysis.

Synthesis, SAR and Docking Studies of Substituted Aryl phenylthiazolyl phenylcarboxamide as potential PTP-1B Inhibitors

The paper synthesizes and evaluates substituted aryl phenylthiazolyl phenylcarboxamides as PTP-1B inhibitors, identifying compound 38 as a potent inhibitor with in vivo metabolic benefits.