Characterising the mechanism of action of an ancient antimicrobial, honey, using modern transcriptomics
D. Bouzo, N. N. Cokcetin, L. Li, G. Ballerin, A. L. Bottomley, J. Lazenby, C. B. Whitchurch, I. T. Paulsen, K. A. Hassan, E. J. Harry
This study uses transcriptomics to show that manuka honey's antimicrobial action involves multiple mechanisms, including SOS response, oxidative damage, and membrane disruption, without promoting bacterial resistance.
bioRxiv · Feb 12, 2020 · PreprintMicrobiology