3-O-methyltolcapone and Its Lipophilic Analogues are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity
T. Poonsiri, D. dell Accantera, V. Loconte, A. Casnati, L. Cervoni, A. Arcovito, S. Benini, A. Ferrari, M. Cipolloni, E. Cacioni, F. De Franco, N. Giacche, S. Rinaldo, C. Folli, F. Sansone, , M. Cianci
This study identifies 3-O-methyltolcapone and its lipophilic analogs as potent TTR stabilizers with improved permeability and reduced toxicity compared to tolcapone.
bioRxiv · Oct 25, 2023Biochemistry