Author

D. E. Brookner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:structural biology· 2 Research Focus:benchmarking· 1 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Research Focus:software / tool· 1

Frequent Co-Authors

D. R. Hekstra· 2 shared C. J. Sheehan· 1 shared I.-S. Kim· 1 shared J. B. Greisman· 1 shared K. M. Dalton· 1 shared M. A. Klureza· 1 shared R. W. Henning· 1 shared S. Russi· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersBiophysics

D. R. Hekstra

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2 papers

Recent·Most cited

MatchMaps: Non-isomorphous difference maps for X-ray crystallography

D. E. Brookner, D. R. Hekstra

MatchMaps computes difference maps between non-isomorphous crystallographic datasets, improving sensitivity to conformational changes without requiring structure refinement of the perturbed state.

Journal of Applied Crystallography · Jun 1, 2024Peer-reviewedBiophysics

Resolving conformational changes that mediate a two-step catalytic mechanism in a model enzyme

J. B. Greisman, K. M. Dalton, D. E. Brookner, M. A. Klureza, C. J. Sheehan, I.-S. Kim, R. W. Henning, S. Russi, D. R. Hekstra

This study identifies conformational changes in DHFR that mediate its two-step catalytic mechanism through experimental perturbations and X-ray diffraction.

bioRxiv · Jun 2, 2023Biophysics