Author

J. B. Greisman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:structural biology· 3 Research Focus:protein structure prediction· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1 Approach:deep learning· 1

Frequent Co-Authors

D. R. Hekstra· 3 shared K. M. Dalton· 3 shared C. J. Sheehan· 2 shared C. Y. Yeh· 2 shared D. E. Shaw· 2 shared L. Willmore· 2 shared M. A. Klureza· 2 shared P. Maragakis· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiophysics

D. R. Hekstra

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Author profile →

5 papers

Recent·Most cited

Resolving conformational changes that mediate a two-step catalytic mechanism in a model enzyme

J. B. Greisman, K. M. Dalton, D. E. Brookner, M. A. Klureza, C. J. Sheehan, I.-S. Kim, R. W. Henning, S. Russi, D. R. Hekstra

This study identifies conformational changes in DHFR that mediate its two-step catalytic mechanism through experimental perturbations and X-ray diffraction.

bioRxiv · Jun 2, 2023Biophysics

A conserved local structural motif controls the kinetics of PTP1B catalysis

C. Y. Yeh, J. A. Izaguirre, J. B. Greisman, L. Willmore, P. Maragakis, D. E. Shaw

This study identifies the PDFG motif as a conserved structural switch controlling WPD-loop conformational transitions in PTP1B, essential for catalytic activity.

bioRxiv · Feb 28, 2023 · PreprintBiophysics

Discovery and validation of the binding poses of allosteric fragment hits to PTP1b: From molecular dynamics simulations to X-ray crystallography

J. B. Greisman, L. Willmore, C. Y. Yeh, F. Giordanetto, S. Shahamadtar, H. Nisonoff, P. Maragakis, D. E. Shaw

The paper uses molecular dynamics simulations to predict fragment binding poses to PTP1b, which are later validated by X-ray crystallography.

bioRxiv · Nov 14, 2022 · PreprintBiophysics

Native SAD Phasing at Room Temperature

J. B. Greisman, K. M. Dalton, C. J. Sheehan, M. A. Klureza, D. R. Hekstra

This paper introduces a room-temperature data collection strategy for native SAD phasing, demonstrating its effectiveness in solving macromolecular structures with high-quality datasets.

bioRxiv · Dec 13, 2021Biophysics

Reciprocalspaceship: A Python Library for Crystallographic Data Analysis

J. B. Greisman, K. M. Dalton, D. R. Hekstra

Reciprocalspaceship is a Python library that provides tools for analyzing crystallographic data by extending pandas with methods for handling diffraction data.

bioRxiv · Feb 3, 2021Biophysics