Multilineage plasticity in prostate cancer through expansion of stem-like luminal epithelial cells with elevated inflammatory signaling
S. Zaidi, J. L. Zhao, J. M. Chan, M. P. Roudier, K. M. Wadosky, A. Gopalan, W. R. Karthaus, J. Choi, K. Lawrence, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, R. Chaligne, I. Linkov, , C. L. Sawyers
The paper identifies stem-like luminal cells with elevated JAK/STAT signaling as a source of multilineage plasticity in prostate cancer, offering a therapeutic target.
bioRxiv · Nov 1, 2021 · PreprintCancer Biology