Author

A. Gopalan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 8 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 6 Organism:human· 6 Approach:statistical model· 6 Research Focus:cell type annotation· 5 Organism:mouse· 5 Research Focus:clustering· 4 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3

Frequent Co-Authors

C. Sawyers· 3 shared H. I. Scher· 3 shared J. Choi· 3 shared P. A. Watson· 3 shared R. Chaligne· 3 shared S. Zaidi· 3 shared W. R. Karthaus· 3 shared Y. Chen· 3 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

C. Sawyers

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1

R. Romero, T. Chu, T. J. Gonzalez-Robles, P. Smith, Y. Xie, H. Kaur, S. Yoder, H. Zhao, C. Mao, W. Kang, M. Pulina, K. E. Lawrence, A. Gopalan, S. Zaidi, K. Yoo, , C. Sawyers

This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.

bioRxiv · Apr 9, 2024Cancer Biology

Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies

S. Zaidi, J. Park, J. M. Chan, M. Roudier, J. L. Zhao, A. Gopalan, K. M. Wadosky, R. A. Patel, E. Sayar, W. R. Karthaus, D. H. Kates, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, , C. Sawyers

The paper uses single-cell analysis to study how cell surface antigen expression changes in treatment-resistant prostate cancer, revealing transcriptional heterogeneity and shared gene regulatory networks between NEPC and SCLC.

bioRxiv · Apr 9, 2024 · PreprintCancer Biology

BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer.

S. Shukla, D. Li, H. Nguyen, J. Conner, G. Bayshtok, W. H. Cho, M. Pachai, N. Teri, E. Campeau, S. Attwell, P. Trojer, I. Ostrovnaya, A. Gopalan, E. Corey, P. Chi, Y. Chen

This study identifies BET inhibitors as effective against GI transcriptome-positive CRPC by targeting HNF1A and HNF4G, improving outcomes in preclinical models.

bioRxiv · Mar 9, 2024 · PreprintCancer Biology

ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity

W. Feng, E. Ladewig, N. Salsabeel, H. Zhao, Y. S. Lee, A. Gopalan, M. Lange, H. Luo, W. Kang, N. Fan, E. Rosiek, E. De Stanchina, Y. Chen, B. S. Carver, C. S. Leslie, C. Sawyers

The paper identifies a stem-like proliferative state in prostate epithelial cells driven by ERG activation, which transitions to luminal cells and is associated with specific chromatin states.

bioRxiv · May 15, 2023Cancer Biology

Pulsed stimulated Brillouin microscopy enables high-sensitivity mechanical imaging of live and fragile biological specimens

F. Yang, C. Bevilacqua, S. Hambura, A. Neves, A. Gopalan, K. Watanabe, M. Govendir, M. Bernabeu, J. Ellenberg, A. Diz-Munoz, S. Köhler, G. Rapti, M. Jechlinger, R. Prevedel

This paper introduces pulsed stimulated Brillouin microscopy to improve mechanical imaging of live biological specimens with reduced phototoxicity and enhanced signal-to-background ratio.

bioRxiv · Nov 10, 2022Bioengineering

Harbingers of Aggressive Prostate Cancer: Precision Oncology Case Studies

J. Cyrta, D. Prandi, A. Arora, D. H. Hovelson, A. Sboner, A. Rodriguez, T. Fedrizzi, H. Beltran, D. R. Robinson, A. Gopalan, L. True, P. Nelson, B. D. Robinson, J. M. Mosquera, S. Tomlins, , M. Rubin

This study identifies molecular features of primary prostate cancer and their relation to metastasis using genomic and histopathological analysis.

bioRxiv · Nov 30, 2021 · PreprintCancer Biology

Multilineage plasticity in prostate cancer through expansion of stem-like luminal epithelial cells with elevated inflammatory signaling

S. Zaidi, J. L. Zhao, J. M. Chan, M. P. Roudier, K. M. Wadosky, A. Gopalan, W. R. Karthaus, J. Choi, K. Lawrence, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, R. Chaligne, I. Linkov, , C. L. Sawyers

The paper identifies stem-like luminal cells with elevated JAK/STAT signaling as a source of multilineage plasticity in prostate cancer, offering a therapeutic target.

bioRxiv · Nov 1, 2021 · PreprintCancer Biology

Chromatin accessibility profiles of castration-resistant prostate cancers reveal novel subtypes and therapeutic vulnerabilities

F. Tang, S. Wang, C. K. Wong, C. J. Lee, S. Cohen, J. Park, C. E. Hill, K. Eng, R. Bareja, T. Han, E. M. Liu, A. Palladino, W. Di, D. Gao, W. Abida, , E. Khurana

This study identifies four subtypes of castration-resistant prostate cancer using ATAC-seq and RNA-seq data, revealing novel therapeutic targets and classification for 370 patients.

bioRxiv · Oct 26, 2020 · PreprintCancer Biology

GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistance

C. L. Sawyers, E. Lee, J. Wongvipat, D. Choi, P. Wang, D. Zheng, P. A. Watson, A. Gopalan

This study identifies GREB1 as a driver of antiandrogen resistance in prostate cancer by amplifying androgen receptor output through enhanced DNA binding and p300 recruitment.

bioRxiv · Oct 2, 2018Cancer Biology