Author

C. L. Sawyers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:organoid / primary culture· 2

Frequent Co-Authors

A. Barlas· 2 shared A. Gopalan· 2 shared C. Wu· 2 shared C.-T. Chen· 2 shared J. Garcia-Aguilar· 2 shared J. J. Smith· 2 shared J. Shia· 2 shared P. A. Watson· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

A. Barlas

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Author profile →

5 papers

Recent·Most cited

NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer

J. J. Li, A. Vasciaveo, D. Karagiannis, Z. Sun, X. Chen, F. Socciarelli, Z. Frankenstein, M. Zou, T. Pannellini, Y. Chen, K. Gardner, B. D. Robinson, J. de Bono, C. Abate-Shen, M. A. Rubin, , M. M. Shen

This study identifies NSD2 as a key driver of lineage plasticity and castration-resistance in neuroendocrine prostate cancer, showing its inhibition can restore sensitivity to AR inhibitors.

bioRxiv · Jul 18, 2023 · PreprintCancer Biology

A new immunocompetent rectal cancer model to study radiation therapy

J. K. Kim, C. Wu, M. Del Latto, Y. Gao, S.-H. Choi, M. Kierstead, C.-E. G. Sauve, C. Firat, A. C. Perez, J. Sillanpaa, C.-T. Chen, K. E. Lawrence, P. B. Paty, F. M. Barriga, J. Shia, , J. J. Smith

This paper introduces a mouse model of rectal cancer that mimics human tumor progression and radiation response for preclinical studies.

bioRxiv · Feb 7, 2022 · PreprintCancer Biology

Multilineage plasticity in prostate cancer through expansion of stem-like luminal epithelial cells with elevated inflammatory signaling

S. Zaidi, J. L. Zhao, J. M. Chan, M. P. Roudier, K. M. Wadosky, A. Gopalan, W. R. Karthaus, J. Choi, K. Lawrence, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, R. Chaligne, I. Linkov, , C. L. Sawyers

The paper identifies stem-like luminal cells with elevated JAK/STAT signaling as a source of multilineage plasticity in prostate cancer, offering a therapeutic target.

bioRxiv · Nov 1, 2021 · PreprintCancer Biology

A rectal cancer model establishes a platform to study individual responses to chemoradiation

K. Ganesh, C. Wu, K. P. O'Rourke, M. Adileh, B. C. Szeglin, I. Wasserman, M. R. Marco, M. Shady, Y. Zheng, W. R. Karthaus, H. H. Won, S.-H. Choi, R. A. Pelossof, A. Barlas, E. Pappou, , J. J. Smith

This study develops a rectal cancer organoid model that mimics patient tumor responses to chemoradiation and metastasis in mice.

bioRxiv · May 22, 2019 · PreprintCancer Biology

GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistance

C. L. Sawyers, E. Lee, J. Wongvipat, D. Choi, P. Wang, D. Zheng, P. A. Watson, A. Gopalan

This study identifies GREB1 as a driver of antiandrogen resistance in prostate cancer by amplifying androgen receptor output through enhanced DNA binding and p300 recruitment.

bioRxiv · Oct 2, 2018Cancer Biology