J. M. Chan

Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies

The paper uses single-cell analysis to study how cell surface antigen expression changes in treatment-resistant prostate cancer, revealing transcriptional heterogeneity and shared gene regulatory networks between NEPC and SCLC.

Peptidoglycan fragment release and NOD activation by commensal Neisseria species from humans and other animals

This study examines PG fragment release and NOD activation in nonpathogenic Neisseria species from humans and animals, finding species-specific differences in PG release and NOD responses.

Bacterial surface lipoproteins mediate epithelial microinvasion by Streptococcus pneumoniae

This study investigates how pneumococcal lipoproteins mediate epithelial microinvasion and finds that differential lipoprotein repertoires do not significantly impact microinvasion, suggesting post-translational modifications may be responsible.

HaloTag display enables quantitative single-particle characterization and functionalization of engineered extracellular vesicles

The paper develops a HaloTag-based system for quantitatively characterizing engineered proteins on extracellular vesicles and compares it to antibody labeling.

Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer

This study shows that CRACD, an actin regulator, suppresses neuroendocrine plasticity and immune evasion in SCLC by modulating NOTCH1 and EZH2 pathways, suggesting EZH2 blockade as a potential therapy.

CD39 Identifies Tumor-Reactive CD8 T cells in Patients With Lung Cancer

This study identifies CD39 as a marker for tumor-reactive CD8 T cells in lung cancer, showing its association with clinical outcomes and response to immune checkpoint therapy.

Multilineage plasticity in prostate cancer through expansion of stem-like luminal epithelial cells with elevated inflammatory signaling

The paper identifies stem-like luminal cells with elevated JAK/STAT signaling as a source of multilineage plasticity in prostate cancer, offering a therapeutic target.

Regional and clonal T cell dynamics at single cell resolution in immune checkpoint blockade

This study uses scTCR/RNA-seq to analyze T cell dynamics in lung cancer patients before and after ICB, finding regional heterogeneity and clonal persistence associated with clinical responses.

The AmiC/NlpD pathway dominates peptidoglycan breakdown in Neisseria meningitidisand affects cell separation, NOD1 agonist production, and infection

This study shows that the AmiC/NlpD pathway in N. meningitidis produces PG-derived peptides that activate NOD1 and are essential for cell separation and infection.

Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformation

The paper identifies molecular mechanisms of neuroendocrine transformation in lung cancer using multi-omic analysis of tumors and clinical samples.

Single cell profiling reveals novel tumor and myeloid subpopulations in small cell lung cancer

The paper profiles single-cell transcriptomes of SCLC subtypes to identify novel tumor and myeloid subpopulations and their associations with metastasis and immune microenvironment changes.

Cell-free DNA as a biomarker for prostate cancer: elevated concentration and decreased fragment size

This study finds that higher plasma cfDNA concentrations and smaller fragment sizes are associated with more advanced prostate cancer.