Targeting tRNA-Synthetase Interactions towards Novel Therapeutic Discovery Against Eukaryotic Pathogens
P. Kelly, F. Hadi-Nezhad, D. Liu, T. J. Lawrence, R. J. Linington, M. Ibba, D. H. Ardell
This paper identifies parasite-specific tRNA-synthetase interactions as a target for broad-spectrum anti-trypanosomal drugs, validated through natural product inhibitors with no human homolog activity.
bioRxiv · Jul 23, 2019Microbiology