Author

D. H. Chye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. P. C. Lim· 2 shared S. K. K. Wong· 2 shared A. D. T. Barrett· 1 shared B. H. Tan· 1 shared B. J. Hanson· 1 shared B. Young· 1 shared C. E. Z. Chan· 1 shared C. E.-Z. Chan· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMicrobiology

A. P. C. Lim

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

The cellular characterisation of SARS-CoV-2 spike protein in virus-infected cells using Receptor Binding Domain-binding specific human monoclonal antibodies.

C. E.-Z. Chan, C.-G. Ng, A. P. C. Lim, S. G.-K. Seah, D. H. Chye, S. K. K. Wong, J.-H. Lim, V. Z.-Y. Lim, S. K. Lai, P.-S. Wong, K.-M. Leong, Y. Liu, R. Sugrue, B. H. Tan

This paper uses monoclonal antibodies to study the conformation and localization of the SARS-CoV-2 spike protein's receptor-binding domain in infected cells, revealing its presence in the Golgi complex and its role in cell-to-cell transmission.

bioRxiv · Dec 6, 2021 · PreprintMicrobiology

The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody

C. E. Z. Chan, S. G. K. Seah, D. H. Chye, S. Massey, M. Torres, A. P. C. Lim, S. K. K. Wong, J. J. Y. Neo, P. S. Wong, J. H. Lim, G. S. L. Loh, D. L. Wang, J. D. Boyd-Kirkup, S. Guan, D. Thakkar, , B. J. Hanson

The paper identifies SC31, a potent SARS-CoV-2 neutralizing antibody, and shows that its Fc-mediated effector functions are critical for its therapeutic efficacy in vivo.

bioRxiv · Oct 26, 2020Microbiology