Human telomere repeat binding factor TRF1 replaces TRF2 bound to shelterin core hub TIN2 when TPP1 is absent
C. Hofr, T. Janovic, M. Stojaspal, P. Veverka, D. Horakova
The paper uses single-molecule techniques to show TRF1 can replace TRF2 on TIN2 when TPP1 is absent, and TPP1 enables simultaneous binding of both TRF1 and TRF2 to TIN2.
bioRxiv · Oct 5, 2018Biochemistry