Functional and structural consequences of epithelial cell invasion by Bordetella pertussis adenylate cyclase toxin
C. Angely, D. Ladant, E. Planus, B. Louis, M. Filoche, A. Chenal, d. ISABEY
This study investigates how Bordetella pertussis adenylate cyclase toxin (CyaA) alters the structure and function of A549 alveolar epithelial cells by increasing intracellular cAMP, leading to cell rounding, actin remodeling, and impaired migration and wound healing.
bioRxiv · Jan 31, 2020Cell Biology