Purifying selection on noncoding deletions of human regulatory elements detected using their cellular pleiotropy
D. W. Radke, J. H. Sul, D. J. Balick, S. Akle, Alzheimer's Disease Neuroimaging Initiative, R. C. Green, S. R. Sunyaev
The paper uses genomic deletions to assess purifying selection on noncoding regulatory elements, finding preservation of DHS and enhancer sites but not transcribed or heterochromatin regions.
bioRxiv · May 19, 2020Evolutionary Biology