Author

S. R. Sunyaev

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Bloemendal· 1 shared A. Ganna· 1 shared A. R. Martin· 1 shared Alzheimer's Disease Neuroimaging Initiative· 1 shared B. M. Neale· 1 shared C. W. K. Chiang· 1 shared D. J. Balick· 1 shared D. Reich· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperEvolutionary Biology

A. Bloemendal

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Author profile →

3 papers

Recent·Most cited

Purifying selection on noncoding deletions of human regulatory elements detected using their cellular pleiotropy

D. W. Radke, J. H. Sul, D. J. Balick, S. Akle, Alzheimer's Disease Neuroimaging Initiative, R. C. Green, S. R. Sunyaev

The paper uses genomic deletions to assess purifying selection on noncoding regulatory elements, finding preservation of DHS and enhancer sites but not transcribed or heterochromatin regions.

bioRxiv · May 19, 2020Evolutionary Biology

Signals of polygenic adaptation on height have been overestimated due to uncorrected population structure in genome-wide association studies

M. Sohail, R. M. Maier, A. Ganna, A. Bloemendal, A. R. Martin, M. C. Turchin, C. W. K. Chiang, J. N. Hirschhorn, M. J. Daly, N. Patterson, B. M. Neale, I. Mathieson, D. Reich, S. R. Sunyaev

The paper shows that polygenic adaptation signals for height are overestimated due to uncorrected population structure in GWAS data.

bioRxiv · Jul 9, 2018Evolutionary Biology

Error-prone bypass of DNA lesions during lagging strand replication is a common source of germline and cancer mutations

V. Seplyarskiy, E. E. Akkuratov, N. V. Akkuratova, M. A. Andrianova, S. I. Nikolaev, G. A. Bazykin, I. Adameyko, S. R. Sunyaev

The paper identifies error-prone bypass of DNA lesions on the lagging strand as a major source of human germline and cancer mutations, supported by mutational asymmetry analysis and experimental validation.

bioRxiv · May 26, 2018Biochemistry