Adaptive changes in the fungal cell wall mediate copper homeostasis
C. Probst, S. Garcia-Santamarina, J. T. Brooks, I. Van Der Kloet, D. J. Thiele, J. A. Alspaugh
This study identifies Cbi1/Bim1 as a copper-binding protein in Cryptococcus neoformans that links copper homeostasis to adaptive changes in the fungal cell wall, including chitin and chitosan levels, and modulates host immune responses.
bioRxiv · Dec 14, 2021 · PreprintMicrobiology