The N34S mutation of SPINK1 may impact the kinetics of trypsinogen activation to cause early trypsin release in the pancreas
Z. Sun, I. Kolossvary, D. Kozakov, M. Sahin-Toth, S. Vajda
The paper shows that the N34S mutation in SPINK1 reduces its inhibitory efficiency, leading to earlier trypsin release in the pancreas due to kinetic effects and autocatalytic conversion.
bioRxiv · Aug 21, 2020 · PreprintBiophysics