J. Wang

Dual CD40/CD28 co-stimulation reprograms the solid-tumor microenvironment to unleash CAR-T and endogenous anti-tumor immunity

This paper introduces LACO-Stim, a co-stimulatory molecule that enhances CAR-T cell therapy by reprogramming the tumor microenvironment to support endogenous anti-tumor immunity.

Tamoxifen and Doxorubicin Synergistically Target Estrogen Receptor beta-Mutant p53-p73 Axis, a Therapeutically Actionable Vulnerability in Triple Negative Breast Cancer

This paper shows that Tamoxifen and Doxorubicin together target the ER beta-mutant p53-p73 axis in TNBC, enhancing cell death through apoptosis and ferroptosis.

EBNA1 INHIBITORS REVEAL CDC7 AND POU2F1 AS DIRECT FUNCTIONAL TARGETS IN EBV EPITHELIAL CANCERS

This study identifies CDC7 and POU2F1 as direct targets of EBNA1 in EBV+ epithelial cancers using VK1727 inhibition, revealing new therapeutic strategies.

Multi-omic profiling of human and mouse dorsal root ganglia enables targeted gene delivery to nociceptors

The paper identifies cis-regulatory elements for targeted gene delivery to nociceptors using multi-omic profiling and develops a sequence-based model to design synthetic enhancers.

Characterizing cellular subpopulations critical to treatment response in autoimmune diseases

The paper identifies treatment response-associated cell subpopulations in autoimmune diseases by integrating single-cell and bulk data from IBD and PsO patients, revealing key pathways and cell types involved in response or non-response.

Perturbational single-cell profiling of patient tumors defines lineage- and context-specific programs of innate immune resistance

The paper uses patient tumor samples to identify lineage- and context-specific mechanisms of innate immune resistance through perturbational single-cell RNA sequencing.

Why is there so much variability in crop multi-model studies?

The paper investigates variability in crop model studies and finds parameter uncertainty contributes more than twice as much as structural uncertainty to total variability.

Histone marks enable formation of immiscible phase-separated chromatin compartments

The paper shows that histone marks drive phase-separated chromatin compartments, influencing gene expression and cancer progression through the CBX7-PRC1 complex.

A drop dispenser for simplifying on-farm detection of foodborne pathogens

The paper develops a drop dispenser for on-farm detection of foodborne pathogens using LAMP, achieving performance comparable to commercial pipettors at a low cost.

Coronavirus Nucleocapsid Protein Enhances the binding of p-PKCα to RACK1: Implications for Inhibition of Nucleocytoplasmic Trafficking and Suppression of the Innate Immune Response

This study identifies how the coronavirus N protein disrupts nucleocytoplasmic trafficking and suppresses the innate immune response by promoting RACK1-PKC interaction and NUP62 phosphorylation.

ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota

This study shows ASB3 worsens inflammatory bowel disease by destabilizing TRAF6 and altering gut microbiota, suggesting ASB3 inhibition could be a therapeutic strategy.

Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast

The paper humanizes yeast U1 snRNP components to study 5 ss recognition, finding that U1C ZnF substitution causes splicing defects and mitochondrial dysfunction.

Adaptive Functions of Structural Variants in Human Brain Development

This study identifies human-specific structural variants in rhesus macaques, showing their impact on human brain development through gene expression changes.

Aberration correction for deformable mirror based remote focusing enables high-accuracy whole-cell super-resolution imaging

This paper develops a deformable mirror-based remote focusing system to enable high-accuracy whole-cell super-resolution imaging with uniform resolution across thick samples.

A Collaborative DNA Barcode Library for the Diptera of Churchill, Canada: Exploration of Biodiversity and Biogeography

The paper presents a DNA barcode library for Diptera in Churchill, Canada, revealing biodiversity patterns and molecular evolution insights.

Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1

This study assesses the antigenic properties and immune evasion of the SARS-CoV-2 variant BA.2.87.1, finding it less resistant to neutralizing antibodies than JN.1 but with compensatory deletions in the NTD.

Rice OsPLATZ3 controls ROS homeostasis by inhibiting ROS-Scavenging Activity during Tapetum Degeneration

This study identifies OsPLATZ3 as a regulator of ROS homeostasis during tapetum degeneration in rice, showing its role in suppressing ROS scavenging and causing male sterility.

Spatial Transcriptomics of Spinal Ependymoma in NF2-related Schwannomatosis

This study uses spatial transcriptomics to analyze a spinal ependymoma tumor, revealing cellular heterogeneity and potential developmental hierarchy within the ependymal cell lineage.

Targeting GFPT2 to reinvigorate immunotherapy in EGFR-mutated NSCLC

This study identifies GFPT2 as a metabolic checkpoint in EGFR-mutated NSCLC that promotes immune evasion, and shows that targeting GFPT2 enhances PD-1 blockade therapy.

pTAC3 and pTAC14 are required for binding of plastid-encoded RNA polymerase to DNA

The paper shows that PAP1/pTAC3 and PAP7/pTAC14 are required for RpoB binding to DNA in Arabidopsis chloroplasts.

Single-cell multiomics reveals a gene regulatory circuit promoting leukemia cell differentiation

This study uses single-cell multiomics to identify a gene regulatory circuit involving SPI1 and CEBPE that promotes differentiation in APL leukemia cells under ATRA treatment.

Super Pangenome of Grapevines Empowers Improvement of the Oldest Domesticated Fruit

The paper assembles and annotates haplotype-resolved genomes of grapevines to uncover genetic diversity and disease resistance mechanisms, identifying structural variants linked to downy mildew resistance.

Analysis of protein levels and solubility in distinct brain regions reveals several elements of the protein homeostasis network that are impacted by aging

The paper analyzes protein levels and solubility in brain regions of aged mice, revealing age-related changes in proteostasis and inflammation markers.

Rapid in situ mutation detection in extracellular vesicle-DNA

This paper introduces a rapid, PCR- and sequencing-free DNA mutation detection method using CRISPR-Cas12a and extracellular vesicles for cancer diagnosis and treatment monitoring.

Phylogenomics resolves a 100-year-old debate regarding the evolutionary history of caddisflies (Insecta: Trichoptera)

This study resolves a century-old debate on caddisfly phylogeny by analyzing genome data from 111 species, clarifying the evolutionary relationships of 'cocoon-makers' and estimating divergence times.

Armored Bicistronic CAR T Cells with Dominant-negative TGF-β Receptor II to Overcome Resistance in Glioblastoma.

This paper develops a tri-modular CAR T cell construct with a dominant-negative TGF-β receptor II to overcome GBM resistance by enhancing T cell function and efficacy in a preclinical model.

EmbB and EmbC Regulate the Sensitivity of Mycobacterium abscessus to Echinomycin

This study identifies EmbB and EmbC as regulators of Mycobacterium abscessus sensitivity to echinomycin, showing that EmbB mutations can partially compensate for EmbC loss and alter cell wall permeability.

Schlafen-11 and -9 are innate immune sensors for intracellular single-stranded DNA

The paper identifies Schlafen-11 and -9 as innate immune sensors that recognize intracellular single-stranded DNA containing CGT motifs, leading to cytokine expression and cell death.

Arginine Di-methylation of RIPK3 Safeguards Necroptosis for Intestinal Homeostasis

This paper shows that arginine di-methylation of RIPK3 by PRMT5 prevents necroptosis in intestinal epithelial cells, maintaining homeostasis and preventing disease.

Host 5-HT affects Plasmodium transmission in mosquitoes via modulating mosquito mitochondrial homeostasis

This study shows that host 5-HT levels influence Plasmodium transmission in mosquitoes by modulating mitochondrial homeostasis and reactive oxygen species.