Author

D. L. Kroetz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 1

Frequent Co-Authors

C. Xiong· 2 shared F. Fattahi· 2 shared K. C. Chua· 2 shared T. B. Stage· 2 shared A. Altman-Merino· 1 shared A. Arab· 1 shared A. C. Ferracini· 1 shared A. Cesiulis· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersPharmacology & Toxicology

C. Xiong

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3 papers

Recent·Most cited

Inhibition of muscarinic receptor signaling protects human enteric inhibitory neurons against platin chemotherapy toxicity

M. N. Richter, S. Farahvashi, R. M. Samuel, H. Majd, A. K. Chemel, J. T. Ramirez, A. Majd, M. D. Scantlen, N. Elder, A. Cesiulis, K. Garcia, T. Joshi, M. G. Keefe, B. Samiakalantari, E. M. Turkalj, , F. Fattahi

This study identifies muscarinic receptor signaling as a key driver of platin-induced enteric neuropathy and shows that its inhibition protects neurons from toxicity.

bioRxiv · Mar 8, 2023 · PreprintPharmacology & Toxicology

Paclitaxel- and vincristine-induced neurotoxicity and drug transport in sensory neurons

C. Mortensen, K. C. Chua, H. S. Hammer, F. Nielsen, O. Poetz, A. F. Svenningsen, D. L. Kroetz, T. B. Stage

This study uses iPSC-derived sensory neurons to investigate paclitaxel and vincristine-induced neurotoxicity and the role of efflux transporters in chemotherapy-induced peripheral neuropathy.

bioRxiv · Feb 7, 2023 · PreprintPharmacology & Toxicology

Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel

C. Xiong, K. C. Chua, T. B. Stage, J. Kim, A. Altman-Merino, D. Chan, K. Saraf, A. C. Ferracini, F. Fattahi, D. L. Kroetz

This study uses human iPSC-derived sensory neurons to investigate the neurotoxic effects of paclitaxel and related drugs, finding dose- and time-dependent toxicity with varying IC50 values.

bioRxiv · Jun 4, 2020Pharmacology & Toxicology