C. Xiong

Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure

This paper investigates how epiberberine binds to a DNA quadruplex structure and shows how modifying the DNA structure enhances binding affinity, leading to a new method for extracting the compound from plant extracts.

Effect of Electroacupuncture Pretreatment on Cognitive Impairment and Mitophagy in Aging Model Rats and its mechanism

This study investigates how electroacupuncture pretreatment affects cognitive impairment and mitophagy in aging rats, finding it improves cognitive function by enhancing mitophagy and mitochondrial function.

Inhibition of muscarinic receptor signaling protects human enteric inhibitory neurons against platin chemotherapy toxicity

This study identifies muscarinic receptor signaling as a key driver of platin-induced enteric neuropathy and shows that its inhibition protects neurons from toxicity.

ASF1 activation PI3K/AKT pathway regulates sexual and asexual development in filamentous ascomycete

The paper identifies SeASF1 and SeH4 as regulators of the PI3K/AKT pathway in filamentous ascomycete, influencing sexual and asexual development through interactions with SeDJ-1 and SePI3K.

ATP and Substrate Binding Regulates Conformational Changes of Human Peroxisomal ABC Transporter ALDP

The paper presents Cryo-EM structures of ABCD1 in different conformational states, revealing how ATP and substrate binding regulate its transport mechanism and disease-related mutations.

Botrytis cinerea BcPTP1 is a late infection phase, cysteine rich protein cytotoxic effector

This study identifies BcPTP1 as a phytotoxic effector secreted by Botrytis cinerea during late infection, which induces cell death and promotes lesion spreading.

Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel

This study uses human iPSC-derived sensory neurons to investigate the neurotoxic effects of paclitaxel and related drugs, finding dose- and time-dependent toxicity with varying IC50 values.

PacBio SMRT-based full-length transcriptome data of Ascosphaera apis mycelium and spore

This paper presents full-length transcriptome data of Ascosphaera apis mycelium and spore using PacBio SMRT sequencing, providing high-quality transcripts for genome and transcriptome annotation improvements.

Evolution and variation of 2019-novel coronavirus

The paper analyzes the evolution and variation of 2019-nCoV by comparing genomic sequences from multiple isolates, identifying amino acid variations and estimating the molecular clock and most recent common ancestor.