Temporal landscape of mitochondrial proteostasis governed by the UPRmt
L. Uoselis, R. Lindblom, M. Skulsuppaisarn, G. Khuu, T. N. Nguyen, D. L. Rudler, A. Filipovska, R. B. Schittenhelm, M. Lazarou
This study develops MitoPQ, a functional proteomics framework, to analyze how the UPRmt maintains mitochondrial proteostasis during stress and identifies oxidative phosphorylation as a key target.
bioRxiv · Nov 30, 2022Cell Biology