R. B. Schittenhelm

Loss of endogenous estrogen alters mitochondrial metabolism and muscle clock-related protein Rbm20 in female mdx mice

This study shows that estrogen loss in female mdx mice reduces exercise capacity and mitochondrial metabolism, but estrogen replacement therapy can reverse these effects and upregulate Rbm20.

Structure of a Rhs effector clade domain identifies new mechanistic insights into type VI secretion system toxin delivery.

The paper presents the structure of Tse15, a T6SS Rhs effector from Acinetobacter baumannii, revealing a novel mechanism for toxin delivery and activation involving auto-cleavage and domain interaction.

An obligate aerobe adapts to hypoxia by hybridising fermentation with carbon storage

This study reveals how Mycobacterium smegmatis adapts to hypoxia by combining fermentative hydrogen production with carbon storage through lipid droplets.

Atmospheric hydrogen oxidation extends to the domain archaea

This study shows that archaea, like bacteria, oxidize atmospheric hydrogen and carbon monoxide, revealing a cross-domain metabolic trait with ecological and evolutionary significance.

Temporal landscape of mitochondrial proteostasis governed by the UPRmt

This study develops MitoPQ, a functional proteomics framework, to analyze how the UPRmt maintains mitochondrial proteostasis during stress and identifies oxidative phosphorylation as a key target.

Male mammalian meiosis and spermiogenesis is critically dependent on the shared functions of the katanins KATNA1 and KATNAL1

This study identifies KATNA1 and KATNAL1 as critical for male meiosis and spermiogenesis, showing their roles in spindle formation, cytokinesis, and sperm structure.

Fibre-specific mitochondrial protein abundance is linked to resting and post-training mitochondrial content in human muscle.

The paper examines fibre-specific mitochondrial protein abundance in human muscle before and after training, finding that most differences are linked to mitochondrial content rather than fibre-type-specific remodelling.

Energy extraction from air: structural basis of atmospheric hydrogen oxidation

This paper determines the structure of a mycobacterial hydrogenase and explains how it selectively oxidizes atmospheric H2 while avoiding O2, enabling energy extraction from air.

Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression via GTP

This paper identifies a non-canonical, methyltransferase-independent mechanism by which EZH2 promotes melanoma progression through interactions with IMPDH2 and GTP synthesis.

Ubr1-induced selective endo-phagy/autophagy protects against the endosomal and Ca2+-induced proteostasis disease stress

This study identifies Ubr1 as a ubiquitin ligase that promotes endo-phagy/autophagy to protect against endosomal and Ca2+-induced proteostasis stress.

A nitrite-oxidizing bacterium constitutively consumes atmospheric hydrogen

This study shows Nitrospira moscoviensis oxidizes atmospheric hydrogen using a high-affinity hydrogenase, enhancing its growth and survival under varying nitrite conditions.

MOV10 facilitates messenger RNA decay in an N6-methyladenosine (m6A) dependent manner to maintain the mouse embryonic stem cells state

The paper identifies MOV10 as a new m6A-reader that facilitates mRNA decay via m6A to regulate the WNT/β-CATENIN pathway and maintain mouse embryonic stem cell state.

Genetic and pharmacological evidence for kinetic competition between alternative poly(A) sites in yeast

The paper investigates kinetic competition between alternative poly(A) sites in yeast using genetic and pharmacological approaches, showing that nucleotide levels and RNAP II dynamics influence polyadenylation site selection.

Mycobacteria tolerate carbon monoxide by remodelling their respiratory chain

This study shows Mycobacterium smegmatis resists carbon monoxide by using cytochrome bd oxidase and shows minimal proteomic changes.

EZH2 Abundance Regulated by UHRF1/UBE2L6/UBR4 Ubiquitin System is the Potential Therapeutic Target to Trigger Pigmented Phenotype in Melanoma

The paper identifies the UHRF1/UBE2L6/UBR4 ubiquitin system as a regulator of EZH2 abundance, which controls pigmentation in melanoma by influencing melanin biosynthesis.

The cryo-EM structure of the neurofibromin dimer reveals the molecular basis for von Recklinghausen disease

This paper determines the cryo-EM structure of full-length NF1, revealing its autoinhibited conformation and providing insights into disease mechanisms and therapeutic strategies.

Periplasm homeostatic regulation maintains spatial constraints essential for cell envelope processes and cell viability

This study shows that elongated Lpp in E. coli counteracts periplasmic enlargement through homeostatic mechanisms involving Lpp tilting and abundance reduction, impacting cell envelope processes and viability.

Spliced peptides and cytokine driven changes in the immunopeptidome of melanoma

This study identifies spliced peptides and cytokine-driven changes in the immunopeptidome of melanoma, showing conserved immunogenic peptides across patients.

Structural analysis of the PTEN:P-Rex2 signalling node reveals how cancer-associated mutations coordinate to hyperactivate Rac1

The paper investigates the PTEN:P-Rex2 complex, identifying how cancer mutations disrupt its inhibitory function and hyperactivate Rac1 signaling.

A Data-Independent-Acquisition-based proteomic approach towards understanding the acclimation strategy of Microchloropsis gaditana CCMP526 in hypersaline conditions

This study uses proteomics to analyze how Microchloropsis gaditana adapts to high salinity, identifying key proteins and pathways involved in acclimation.

Cellular and structural basis of synthesis of the unique intermediate dehydro-F420-0 in mycobacteria

This study resolves the biosynthesis pathway of F420 in mycobacteria by showing phosphoenolpyruvate, not 2-phospholactate, is the precursor and identifies the structural mechanism of dehydro-F420-0 production.

Restriction of essential amino acids dictates the systemic response to dietary protein dilution

This study shows that restricting essential amino acids, not non-essential ones, drives systemic metabolic responses to dietary protein dilution and genetic amino acid transport loss.

Interaction of Plasmodium falciparum Casein kinase 1 (PfCK1) with components of host cell protein trafficking machinery.

The paper identifies host and parasite proteins involved in a trafficking pathway that facilitates PfCK1 secretion and membrane localization during Plasmodium falciparum infection.

Carbon monoxide dehydrogenases enhance bacterial survival by oxidising atmospheric CO

This study shows that carbon monoxide dehydrogenases enhance bacterial survival by providing a supplemental energy source during organic carbon starvation.