Probing remdesivir nucleotide analogue insertion to SARS-CoV-2 RNA dependent RNA polymerase in viral replication
M. E. Romero, C. Long, D. La Rocco, A. M. Keerthi, D. Xu, J. Yu
This study computationally examines how remdesivir nucleotide analogue binds and inserts into SARS-CoV-2 RdRp, showing it has a lower energy barrier than ATP insertion.
bioRxiv · Jul 12, 2021Biophysics