Disruption of redox balance in glutaminolytic triple negative breast cancer by inhibition of glutamate export and glutaminase
H. Choi, M. Gupta, C. Hensley, H. Lee, Y.-T. Lu, A. Pantel, D. Mankoff, R. Zhou
This study shows that inhibiting glutaminase and xCT in TNBC disrupts redox balance, enhances chemotherapy efficacy, and can be monitored non-invasively using PET.
bioRxiv · Nov 19, 2023Cancer Biology